How are we addressing gastric intestinal metaplasia ?
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مقایسه موسین موجود در سلولهای مخاط معده بیماران مبتلا به گاستریت هلیکوباکترپیلوری با افراد طبیعی
ABSTRACT Gastric cancer (GC) is one of the most common cancers in the world. Despite some improvement in the treatment of this type of cancer, the 5-year survival rate has been already remained low. Therefore further exploration of biological features and causes of gastric cancer is needed to reduce its occurrence. In sequential changes from superficial gastritis to dysplasia and cance...
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BACKGROUND AND AIMS Gastric intestinal metaplasia, which is mainly induced by Helicobacter pylori infection, is thought to be a precancerous lesion of gastric adenocarcinoma. Intestinal metaplastic mucosa expresses intestine specific homeobox genes, Cdx1 and Cdx2, in the human gastric mucosa. We and others have reported that ectopic expression of Cdx2 in the gastric epithelium generates intesti...
متن کاملCytological studies on the enterochromaffin cells in the intestinal metaplasia.
NABEYAMA, A. and OGATA, T. Cytological Studies on the Eaterochrounafin Cells in the Intestinal Metaplasia. Tohoku J. exp. Med., 1971, 105 (4),355-363 The enterochromaffin cells (Ec-cells) in the normal and pathological antral mucosa of the human stomach were examined. It was clarified that the Ec-cells are observed only in the mucosa with intestinal metaplasia, and never in the normal mucosa. W...
متن کاملGastric Intestinal Metaplasia in an Underserved Population in the USA: Prevalence, Epidemiologic and Clinical Features
Gastric intestinal metaplasia is an important stage in the development of gastric cancer. Limited data is available regarding the prevalence of gastric intestinal metaplasia in the United States. We conducted a retrospective review of esophagogastroduodenoscopies performed in our endoscopy unit between the months of April and October 2010 to evaluate the prevalence and the epidemiologic and end...
متن کاملCDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5.
Intestinal metaplasia of the stomach, a mucosal change characterized by the conversion of gastric epithelium into an intestinal phenotype, is a precancerous lesion from which intestinal-type gastric adenocarcinoma arises. Chronic infection with Helicobacter pylori is a major cause of gastric intestinal metaplasia, and aberrant induction by H. pylori of the intestine-specific caudal-related home...
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